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Bone Marrow Transplantation

The Bone Marrow Transplantation Unit of Davidoff Oncology Center, Rabin Medical Center, is headed by Dr. Moshe Yeshurun, a leading specialist in stem cells and treatment of hematological diseases. Bone marrow transplantation is one of the greatest achievements of modern medicine. Currently, this is the most efficient method of treatment of patients suffering from leukemia, lymphodenoma, myeloma, breast cancer, and other diseases associated with immunodeficiency. In Israel, this field of medical science is given the utmost priority, and the achievements of Rabin Medical Center experts have been widely recognized to be among the world's best.

The Bone Marrow Transplantation Unit of Rabin Medical Center is equipped with state-of-the-art medical devices. Its highly-qualified personnel includes hematologists, oncologists, radiologists, infectious disease specialists, and psychologists. Rabin Medical Center is constantly involved in serious oncology and haemato-oncology research.

Following is the list of diseases requiring bone marrow or stem cells transplantation

Congenial diseases: adrenoleukodystrophy, Griscellis syndrome type 2, Hurler syndrome, metachromatic leucodystrophy, thalassanemia, hemophagocytic lymphohistiocytosis, Wiskott Aldrich syndrome, congenial metabolism disorders. Evoked diseases: acute lymphoblastic leukemia, chronic lymphatic leukemia, acute myeloid leukemia, chronic myelogenous leukemia, aplastic anemia, Hodgkin lymphom, multiple myeloma, myelodysplastic syndrome, Non-Hodgkin lymphoma, paroxysmal nocturnal hemoglobinuria, acute radiation syndrome

Bone Marrow Exfusion

The exfusion is performed under general anesthesia; in some cases, epidural (spinal) anesthesia may be recommended. Bone marrow is collected using large-diameter needles through multiple punctures on the both sides of the wing of ilium. The quantity of bone marrow thus obtained should not exceed 10 – 15 ml per one kilogram of the donor’s body weight. To prevent the development of acute graft-versus-host reaction, T-lymphocytes can be removed from allogenic bone marrow before the implantation by using monoclonal antibodies. Autologic bone marrow can be purified of malignant cells using cytostatic agents. After being collected, autologic bone marrow is usually subjected to cryoconservation using the dimethylsulphoxide (DMSO) cryoprotectant and programmed freeze. The frozen cells are stored in liquid nitrogen at the temperature of – 196 °C. The process of bone marrow exfusion does not lead to any serious complications in 99 percent of cases; however, complications may be caused due to anesthesia effects or rapid blood loss. The bone marrow infusion in allo-BMT or syngeneic BMT is intravenous, by drop administration, within 24 – 48 hours after chemo- or radiotherapy. The autologic bone marrow infusion is performed in the same manner, as promptly as possible after the bone marrow is thawed at a temperature of 42 – 45 °C.

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